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Anti-B2-Glycoprotein I Antibodies
Principle
β2-Glycoprotein I (β2GPI) is a 50 kDa plasma glycoprotein that binds as a cofactor to anionic phospholipids such as cardiolipin. It also interacts with the membranes of activated platelets and endothelial cells, which play a role in the patho
Specimen Requirements
Specimen
Serum
Collection
Collect one 10 mL red-top tube (no anticoagulant or preservative) by standard venipuncture.
Processing
Allow blood to clot and centrifuge at 1600 rpm for 10 minutes to separate serum.
Storage and Transport
- Room temperature: up to 8 hours
- 2-8°C: up to 48 hours
- -20°C or below: for longer storage
Send frozen serum on dry ice. Do not freeze samples in self-defrosting freeze
Minimum Volume
100 µL of serum
Method
Enzyme-Linked Immunosorbent Assay (ELISA)
Normal Range
Negative
Results are reported as negative or positive.
Turnaround Time
7-10 business days
References
- H. Bas de Laat et al. Clin Immunol. 112:161-168; 2004.
- Di Simone et al. Ann Rheum Dis. 64:462-467; 2005.