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Center for Proteomics and Molecular Therapeutics Diseases

Alzheimer's

  • Marc Glucksman
    • Philibert KD, Marr RA, Norstrom EM, Glucksman MJ. Identification and characterization of Aβ peptide interactors in Alzheimer's disease by structural approaches. Front Aging Neurosci. Oct 9;6:265 [2014]. Medline
    • Mott NN, Pinceti E, Rao YS, Przybycien-Szymanska MM, Prins SA, Shults CL, Yang X, Glucksman MJ, Roberts JL, Pak TR. Age-dependent Effects of 17β-estradiol on the dynamics of estrogen receptor β (ERβ) protein-protein interactions in the ventral hippocampus. Mol Cell Proteomics. 13(3):760-79 [2014]. Medline
  • Jun-Yong Choe
    • Kim, J.W., Yang. Y.S., Song. S.S., Na. J.-H, Oh. K.J., Jeong. C.H., Yu. Y.G., Shin, Y.K. 2014. Beta-amyloid oligomers activate apoptotic BAK pore for cytochrome c release Biophys. J. 107(7):1601-1608. (featured in New and Notable by Daniel A. Linseman in Biophysical Journal, Oct. 2014, volume 107, pp1491-1492) [Biophysical Journal]
    • Song, S.S., Lee, W.K., Aluvila, S., Oh, K.J., and Yu, Y.G. 2014. Identification of inhibitors against BAK pore formation using an improved in vitro system. Bull. Korean Chem. Soc. 35(2):419-424. [Korean Chem. Soc.]

Cancer

  • Jun-Yong Choe
    • Mandal, T., Shin, S., Aluvila, S., Chen, H.C., Grieve, C., Choe, J.Y., Cheng, E. H., Hustedt, E. J., Oh, K.J. 2016. Assembly of Bak homodimers into higher order homooligomers in the mitochondrial apoptotic pore. Scientific Reports, Nature Publishing Group, 6: 30763.
    • Chen, D.Y., Lee, Y., Van Tine, B.A., Searleman, A.C., Westergard, T.D., Liu, H., Tu. H.C., Takeda, S., Dong, Y., Piwnica-Worms, D.R., Oh, K.J., Korsmeyer, S.J., Hermone, A., Gussio, R., Shoemaker, R.H., Cheng, E.H., and Hsieh, J.J. 2012. A pharmacologic inhibitor of the protease Taspase1 effectively inhibits breast and brain tumor growth. Cancer Res. 72(3):736-746 (Epub 2011 Dec 13). [NIH]

Cardiovascular & Stroke

  • Donghee Kim
    • Wang J, Kim D. Activation of voltage-dependent K+ channels strongly limits hypoxia-induced elevation of [Ca2+ ]i in rat carotid body glomus cells. J Physiol. Nov 21. doi: 10.1113/JP275275, 2017. [Epub ahead of print]
    • Kim D. Endocytosis: another pathway in receptor-Gq-TASK signalling. J Physiol. 595:6811-6812, 2017.
    • Wang J, Hogan JO, Wang R, White C, Kim D. Role of cystathionine-γ-lyase in hypoxia-induced changes in TASK activity, intracellular [Ca2+] and ventilation in mice. Respir Physiol Neurobiol. 246:98-106, 2017.
    • Gul R, Park DR, Shawl AI, Im SY, Nam TS, Lee SH, Ko JK, Jang KY, Kim D, Kim UH. Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Cyclic ADP-Ribose (cADPR) Mediate Ca2+ Signaling in Cardiac Hypertrophy Induced by β-Adrenergic Stimulation. PLoS One 11:e0149125, 2016.
  • Darryl Peterson
    • Peterson, D.R. E.J. Sukowski, and D. Zikos. Blood-brain barrier transport pathways for cytoprotective thiols. Am J Ther. 2013 Sep-Oct;20(5):469-79. doi: 10.1097/MJT.0b013e31829e8b7f.
    • N. Ikpa, R. Forman, K. Garchow, E. Sukowski, and Peterson, D.R. In Vitro Studies on Degradation of Gamma-L-Glutamyl-L-Cysteine and Gamma-L-Glutamyl-D-Cysteine in Blood: Implications for Treatment of Stroke. Am J Ther. 2015 Jul-Aug;22(4):e97-e106. doi: 10.1097/MJT.0000000000000246.

Fibrosis

  • Darryl Peterson
    • B.L. Riser, F. Najmabadi, K. Garchow, J.L. Barnes, Peterson, D.R., and E. J. Sukowski. Treatment with the matricellular protein CCN3 blocks and/or reverses fibrosis development in obesity with diabetic nephropathy. Am J Pathol. 2014 Nov;184(11):2908-21. doi: 10.1016/j.ajpath.2014.07.009. Epub 2014 Sep 2.

Infection

  • Min Lu
    • Radchenko, M., Nie, R. and Lu, M. (2016) Disulfide crosslinking of a multidrug and toxic compound extrusion transporter impacts multidrug efflux. J. Biol. Chem. 291:9818-9826.
    • Lu, M.(2015) Structures of multidrug and toxic compound extrusion transporters and their mechanistic implications (review) Channels 10(2):88-100.
    • Radchenko, M., Symersky, J., Nie, R. and Lu, M.. (2015) Structural basis for the blockade of MATE multidrug efflux pumps. Nat. Commun. 6:7995
    • Symersky, J., Guo, Y., Wang, J. and Lu, M. (2015) Crystallographic study of a MATE transporter presents a difficult case in structure determination with low-resolution, anisotropic data and crystal twinning Acta Cryst D71 2287-2296.

Kidney Disease

  • Henry Sackin
    • Nanazashvili, M., Sánchez-Rodríguez, J.E., Fosque, B., Bezanilla, F., Sackin, H. (2017). LRET Determination of Molecular Distances during pH Gating of the Mammalian Inward Rectifier Kir1.1b. Biophys J. 114: 88-97.
    • Sackin, H., Nanazashvili, M., and Makino, S. (2015). Direct injection of cell-free Kir1.1 protein into Xenopus oocytes replicates single-channel currents derived from Kir1.1 mRNA. Channels. 9: 196-199.
    • Frindt, G., Li, H., Sackin, H., Palmer, L. G. (2013). Inhibition of ROMK channels by low extracellular K and oxidative stress. Am. J. Physiol. 305 (Renal): F208-F215.

Metabolic Disease / Diabetes

  • Jun-Yong Choe
    • Vaca E., Behrens C., Theccanat T., Choe J.Y., and Dean J.V. (2017) "Mechanistic differences in the uptake of salicylic acid glucose conjugates by tonoplast vesicles isolated from Arabidopsis thaliana." Physiologia Plantarum 161, 322-338.
    • Culbertson A.T., Ehrlich J.J., Choe J.Y., Honzatko R.B., and Zabotina O.A. "Structure of xyloglucan xylosyltransferase 1 reveals simple steric rules that define biological patterns of xyloglucan polymers." Proceedings of the National Academy of Science U S A 115, 6064-6069.
    • Ferraris R.P., Choe J.Y., and Patel C.R. (2018) "Intestinal Absorption of Fructose." Annual Review of Nutrition 2018 May 11. doi: 10.1146/annurev-nutr-082117-051707. [Epub ahead of print]
    • Thomik T., Wittig I., Choe J.Y., Boles E., and Oreb M. (2017 ) "An artificial transport metabolon facilitates improved substrate utilization in yeast." Nature Chemical Biology 13, 1158-1163.
  • Marc Glucksman
    • Shalata A, Ramirez MC, Desnick RJ, Priedigkeit N, Buettner C, Lindtner C, Mahroum M, Abdul-Ghani M, Dong F, Arar N, Camacho-Vanegas O, Zhang R, Camacho SC, Chen Y, Ibdah M, DeFronzo R, Gillespie V, Kelley K, Dynlacht BD, Kim S, Glucksman MJ, Borochowitz ZU, Martignetti JA. Morbid obesity resulting from inactivation of the ciliary protein CEP19 in humans and mice. Am J Hum Genet. 93(6):1061-71 [2013].
  • Ronald Kaplan
    • Sun, J., Mayor, J.A., Kotaria, R., Walters, D.E., and Kaplan, R.S. Molecular Characterization of the Plasma Membrane Citrate Transporter. In preparation for submission to J. Biol. Chem. (2018).
    • Nie, R., Stark, S., Symersky, J., Kaplan, R.S., and Lu, M. Structure and function of the divalent anion/Na+ sympter from Vibrio cholera and a humanized variant. Nature Comm. 8:15009 (2017).

OPHTHALMOLOGY

  • Lisa Ebihara
    • Tong JJ, Minogue PJ, Kobeszko M, Beyer EC, Berthoud VM, Ebihara L. The connexin46 mutant, Cx46T19M, causes loss of gap junction function and alters hemi-channel gating. J Membr Biol. 248:145-155, 2015.
    • Ebihara L, Korzyukov Y, Kothari S, Tong JJ. Cx46 hemichannels contribute to the sodium leak conductance in lens fiber cells. Am J Physiol Cell Physiol. 306:C506-513, 2014.
    • Tong JJ, Sohn BC, Lam A, Walters DE, Vertel BM, Ebihara L. Properties of two cataract-associated mutations located in the NH2 terminus of connexin 46. Am J Physiol Cell Physiol. 304:C823-832, 2013.

Rare/Orphan Diseases

  • Marc Glucksman
    • Rodriguez-Zabala M, Aza-Carmona M, Rivera-Pedroza CI, Belinchón A, Guerrero-Zapata I, Barraza-García J, Vallespin E, Lu M, Del Pozo A, Glucksman MJ, Santos-Simarro F, Heath KE. FGF9 mutation causes craniosynostosis along with multiple synostoses. Hum Mutat. 2017 Nov;38(11):1471-1476. doi: 10.1002/humu.23292. Epub 2017 Jul 25.
    • Evans BR, Mosig RA, Lobl M, Martignetti CR, Camacho C, Grum-Tokars V, Glucksman MJ, Martignetti JA. Mutation of membrane type-1 metalloproteinase, MT1-MMP, causes the multicentric osteolysis and arthritis disease Winchester syndrome. Am J Hum Genet. 91(3):572-6 [2012].

Reproductive health